{"id":1657132,"date":"2025-02-07T18:05:45","date_gmt":"2025-02-07T17:05:45","guid":{"rendered":"https:\/\/pre.efe.com\/?p=1657132"},"modified":"2025-02-07T18:11:29","modified_gmt":"2025-02-07T17:11:29","slug":"scientists-crack-the-code-how-this-hormone-fuels-diabetes-in-obese-people","status":"publish","type":"post","link":"https:\/\/pre.efe.com\/en\/latest-news\/2025-02-07\/scientists-crack-the-code-how-this-hormone-fuels-diabetes-in-obese-people\/","title":{"rendered":"Scientists crack the code: How this hormone fuels diabetes in obese people"},"content":{"rendered":"\n

Logro\u00f1o. Spain, Feb 7 (EFE).\u2014 Researchers have identified the molecular mechanism by which the peptide hormone, adrenomedullin, triggers type 2 diabetes in obese persons, paving the way for new treatment and prevention strategies, according to a study published in Science.<\/p>\n\n\n\n

Led by Germany\u2019s Max Planck Institute, the study involved researchers from Germany, the United States, and Spain, including the Angiogenesis Unit at the Biomedical Research Center of La Rioja (Cibir). Alfredo Mart\u00ednez, director of Cibir\u2019s unit, presented the findings on Friday.<\/p>\n\n\n\n

While previous research linked obesity to type 2 diabetes, the molecular mechanism behind this connection remained unknown.<\/p>\n\n\n\n

Scientists have now demonstrated that fat cells in obese individuals produce excessive levels of adrenomedullin. This regulatory peptide interferes with insulin receptors in endothelial cells, those lining blood vessels, reducing their sensitivity to insulin and contributing to insulin resistance, Mart\u00ednez said.<\/p>\n\n\n\n

Insulin resistance, the hallmark of type 2 diabetes, restricts blood flow to glucose-absorbing organs such as the liver and muscles, further impairing blood sugar regulation.<\/p>\n\n\n

\n
\"\"
Researchers from several countries have identified the molecular mechanism by which the hormone adrenomedullin can cause type 2 diabetes in people with obesity, which lays the foundations for developing new therapeutic strategies aimed at preventing and treating this disease. EFE\/ Raquel Manzanares<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Diabetes is a major global driver of illness, death, and healthcare costs, with the majority of cases linked to obesity-related insulin resistance and type 2 diabetes. This resistance primarily impacts key metabolic tissues, including skeletal muscle, fat, and the liver.<\/p>\n\n\n\n

Blood vessel endothelial cells also contain insulin receptors, and their insulin signaling is believed to play a vital role in metabolic regulation. Research suggests that endothelial insulin resistance may contribute to overall insulin resistance in type 2 diabetes.<\/p>\n\n\n\n

However, the exact mechanisms behind this process remain unclear, and its direct role in the disease has not been conclusively determined.<\/p>\n\n\n\n

Genetic engineering confirms findings
<\/strong>Using advanced genetic engineering techniques, researchers developed conditional knockout models\u2014mice in which the adrenomedullin gene or its receptor was deactivated in specific cells.<\/p>\n\n\n\n

Results showed that obese mice with intact adrenomedullin pathways developed insulin resistance and type 2 diabetes, along with reduced blood flow to key organs.<\/p>\n\n\n\n

However, those lacking the hormone in fat cells or its receptor in endothelial cells did not develop diabetes, despite being equally obese.<\/p>\n\n\n\n

Moreover, researchers found that an adrenomedullin inhibitor prevented insulin resistance in obese mice, reinforcing the hormone\u2019s role as a potential therapeutic target.<\/p>\n\n\n\n

Scientists now see blocking adrenomedullin or its receptor as a promising new strategy for preventing type 2 diabetes, particularly in obese persons. EFE<\/p>\n\n\n\n

rpi-sk<\/p>\n","protected":false},"excerpt":{"rendered":"

Logro\u00f1o. Spain, Feb 7 (EFE).\u2014 Researchers have identified the molecular mechanism by which the peptide hormone, adrenomedullin, triggers type 2 diabetes in obese persons, paving the way for new treatment and prevention strategies, according to a study published in Science. Led by Germany\u2019s Max Planck Institute, the study involved researchers from Germany, the United States, … Read more<\/a><\/p>\n","protected":false},"author":198164264,"featured_media":1657144,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[122140],"tags":[],"class_list":["post-1657132","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"acf":[],"yoast_head":"\nGroundbreaking Study Reveals Hormone's Role in Diabetes Development in Obese People EFE<\/title>\n<meta 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